منابع مشابه
Pseudomonas aeruginosa Elastase
The elastase produced by Pseudomonas aerughosa is probably responsible for the tissue destruction observed during pulmonary and corneal infections by this pathogen. We have synthesized a new substrate, AbzAla-Gly-Leu-Ala-Nba, for P. aeruginosa elastase. Cleavage of the peptide by elastase at pH 7.2 results in 6to 7-fold increase in fluorescence (h,,, 340 nm; X, 415 nm). A sensitive rate assay u...
متن کاملNeutrophil elastase mediates innate host protection against Pseudomonas aeruginosa.
According to the widely accepted view, neutrophil elastase (NE), a neutrophil-specific serine protease, is a major contributor to Pseudomonas aeruginosa infection-associated host tissue inflammation and damage, which in severe cases can lead to death. Herein, we provide for the first time compelling evidence that the host rather employs NE to protect itself against P. aeruginosa infection. Usin...
متن کاملElastase deficiency phenotype of Pseudomonas aeruginosa canine otitis externa isolates.
Pseudomonas aeruginosa veterinary isolates were assayed for elastase and total matrix protease activity. The elastase activity of canine ear isolates was much less than that of strain PAO1 and that of all other veterinary isolates (P < 0.0001). The results indicate that canine ear isolates have a distinct elastase phenotype.
متن کاملAnalysis of the Pseudomonas aeruginosa elastase (lasB) regulatory region.
The enzyme elastase is an important virulence factor of the opportunistic human pathogen Pseudomonas aeruginosa. Previous studies have shown that expression of the P. aeruginosa elastase gene (lasB) requires both an activator protein, LasR, and an N-acylhomoserine lactone compound termed Pseudomonas autoinducer (PAI). In this study, we analyzed the lasB promoter region to learn more about lasB ...
متن کاملProduction of Elastase and Proteinase by Pseudomonas Aeruginosa.
Morihara, Kazuyuki (Shionogi Research Laboratory, Osaka, Japan). Production of elastase and proteinase by Pseudomonas aeruginosa. J. Bacteriol. 88:745-757. 1964.-Some strains of Pseudomonas aeruginosa produced elastase, but the others did not. The elastase-positive strains produced two proteinases (fractions II and III), and the elastase-negative strains produced one proteinase (fraction III). ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97217-0